--- a/include/api/wasmedge/int128.h
+++ b/include/api/wasmedge/int128.h
@@ -16,7 +16,8 @@
 #define WASMEDGE_C_API_INT128_H
 
 #if defined(__x86_64__) || defined(__aarch64__) ||                             \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
 typedef unsigned __int128 uint128_t;
 typedef __int128 int128_t;
 #else
--- a/include/common/int128.h
+++ b/include/common/int128.h
@@ -131,7 +131,8 @@ public:
   constexpr uint128(uint64_t H, uint64_t L) noexcept : Low(L), High(H) {}
 
 #if defined(__x86_64__) || defined(__aarch64__) ||                             \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
   constexpr uint128(unsigned __int128 V) noexcept
       : Low(static_cast<uint64_t>(V)), High(static_cast<uint64_t>(V >> 64)) {}
 #endif
@@ -395,7 +396,8 @@ public:
   constexpr int128(uint128 V) noexcept;
   constexpr int128(int64_t H, uint64_t L) noexcept : Low(L), High(H) {}
 #if defined(__x86_64__) || defined(__aarch64__) ||                             \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
   constexpr int128(__int128 V) noexcept
       : Low(static_cast<uint64_t>(V)), High(V >> 64) {}
 #endif
@@ -539,7 +541,8 @@ public:
 namespace WasmEdge {
 // If there is a built-in type __int128, then use it directly
 #if defined(__x86_64__) || defined(__aarch64__) ||                             \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
 using int128_t = __int128;
 using uint128_t = unsigned __int128;
 #else
--- a/include/ast/instruction.h
+++ b/include/ast/instruction.h
@@ -55,7 +55,8 @@ public:
   Instruction(OpCode Byte, uint32_t Off = 0) noexcept
       : Offset(Off), Code(Byte) {
 #if defined(__x86_64__) || defined(__aarch64__) ||                             \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
     Data.Num = static_cast<uint128_t>(0);
 #else
     Data.Num.Low = static_cast<uint64_t>(0);
@@ -211,7 +212,8 @@ public:
   /// Getter and setter for the constant value.
   ValVariant getNum() const noexcept {
 #if defined(__x86_64__) || defined(__aarch64__) ||                             \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
     return ValVariant(Data.Num);
 #else
     uint128_t N{Data.Num.High, Data.Num.Low};
@@ -220,7 +222,8 @@ public:
   }
   void setNum(ValVariant N) noexcept {
 #if defined(__x86_64__) || defined(__aarch64__) ||                             \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
     Data.Num = N.get<uint128_t>();
 #else
     uint128_t V = N.get<uint128_t>();
@@ -316,7 +319,8 @@ private:
     } Memories;
     // Type 8: Num.
 #if defined(__x86_64__) || defined(__aarch64__) ||                             \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
     uint128_t Num;
 #else
     struct {
--- a/include/common/errinfo.h
+++ b/include/common/errinfo.h
@@ -628,7 +628,8 @@ struct fmt::formatter<WasmEdge::ErrInfo:
           OffFromLow, OffToLow, Bound);
     }
 #elif defined(__x86_64__) || defined(__aarch64__) ||                           \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
     fmt::format_to(std::back_inserter(Buffer),
                    "    Accessing offset from: 0x{:08x} to: 0x{:08x} , Out of "
                    "boundary: 0x{:08x}"sv,
--- a/lib/api/wasmedge.cpp
+++ b/lib/api/wasmedge.cpp
@@ -154,7 +154,8 @@ genWasmEdge_Result(const ErrCode &Code)
 template <typename C>
 inline constexpr ::uint128_t to_uint128_t(C Val) noexcept {
 #if defined(__x86_64__) || defined(__aarch64__) ||                             \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
   return Val;
 #else
   return {/* Low */ Val.low(), /* High */ static_cast<uint64_t>(Val.high())};
@@ -162,7 +163,8 @@ inline constexpr ::uint128_t to_uint128_
 }
 template <typename C> inline constexpr ::int128_t to_int128_t(C Val) noexcept {
 #if defined(__x86_64__) || defined(__aarch64__) ||                             \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
   return Val;
 #else
   return {/* Low */ Val.low(), /* High */ Val.high()};
@@ -174,7 +176,8 @@ template <typename C> inline constexpr :
 template <typename C, typename T>
 inline constexpr C to_WasmEdge_128_t(T Val) noexcept {
 #if defined(__x86_64__) || defined(__aarch64__) ||                             \
-    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__)
+    (defined(__riscv) && __riscv_xlen == 64) || defined(__s390x__) ||   \
+    defined(__alpha__)
   return Val;
 #else
   return C(Val.High, Val.Low);
--- a/lib/system/allocator.cpp
+++ b/lib/system/allocator.cpp
@@ -9,11 +9,10 @@
 
 #if WASMEDGE_OS_WINDOWS
 #include "system/winapi.h"
-#elif defined(HAVE_MMAP) && defined(__x86_64__) || defined(__aarch64__) ||     \
-    defined(__arm__) || (defined(__riscv) && __riscv_xlen == 64) ||            \
-    defined(__s390x__)
-#include <sys/mman.h>
 #else
+#if defined(HAVE_MMAP)
+#include <sys/mman.h>
+#endif
 #include <cctype>
 #include <cstdlib>
 #include <cstring>